Dimauro Ivan

Ruolo Accademico: 

Professore Associato

Area Scientifica: 

Bio-medico

(SSD) Settore Scientifico Disciplinare: 

BIO/13

Dipartimento di Scienze Motorie Umane e della Salute - Sezione: 

Scienze della Salute

Recapiti: 

Università di Roma "Foro Italico" Piazza L. de Bosis 6, 00135,

ivan.dimauro@uniroma4.it

Ricevimento: 

per appuntamento

Curriculum: 

Ivan Dimauro è Professore Associato, settore concorsuale 05/F1, settore scientifico disciplinare BIO/13) presso il Dipartimento di Scienze Motorie, Umane e della Salute, Università degli Studi di Roma “Foro Italico”, afferente all’Unità di Biologia, Genetica e Biochimica.

I suoi interessi principali mirano a definire i meccanismi molecolari indotti dall’attività fisica che possano garantire quello che molti studiosi definiscono un “healthy aging”. In particolare, la sua ricerca si propone di valutare in situazioni fisiologiche o patologiche l’effetto dell’attività fisica a) sui sistemi anti-ossidanti cellulari ed extracellulari; b) sull’espressione di specifiche proteine da stress come le heat shock proteins (HSPs); c) sui cambiamenti a livello del genoma come la lunghezza dei telomeri, i livelli di metilazione del DNA, l’acetilazone proteica e l’espressione di proteine deputate al controllo della stabilità genomica.

 

Ivan Dimauro is an Associate Professor at the Department of Motor Science, Humanities And of Health, University of Rome "Foro Italico", in the Department of Biology, Genetics and Biochemistry.

His main interests are to define the molecular mechanisms induced by physical activity that can guarantee what many scientists call "healthy aging." In particular, his research aims to evaluate in physiological or pathological situations the effect of physical activity on a) cellular and extracellular antioxidant systems; B) Expression of specific stress proteins such as heat shock proteins (HSPs); C) genomic changes such as length of telomeres, DNA methylation levels, protein acetylation, and the expression of proteins involved into genomic stability control.

Curriculum Scientifico: 

Most relevant publications

  1. Dimauro I, Paronetto MP, Caporossi D. Exercise, redox homeostasis and the epigenetic landscape [published online ahead of print, 2020 Feb 26]. Redox Biol. 2020;101477. doi:10.1016/j.redox.2020.101477
  2. Antonioni A, Dimauro I, Fantini C, et al. αB-crystallin response to a pro-oxidant non-cytotoxic environment in murine cardiac cells: An "in vitro" and "in vivo" study [published online ahead of print, 2020 Mar 26]. Free Radic Biol Med. 2020;S0891-5849(19)32445-1. doi:10.1016/j.freeradbiomed.2020.03.013
  3. Dimauro I, Antonioni A, Mercatelli N, Grazioli E, Fantini C, Barone R, Macaluso F, Di Felice V, Caporossi D. The early response of αB-crystallin to a single bout of aerobic exercise in mouse skeletal muscles depends upon fiber type and oxidative stress level. Redox Biol. 2019 Apr 3;24:101183. doi: 10.1016/j.redox.2019.101183.
  4. Dimauro I, Sgura A, Pittaluga M, Magi F, Fantini C, Mancinelli R, Sgadari A, Fulle S, Caporossi D. Regular exercise participation improves genomic stability in diabetic patients: an exploratory study to analyse telomere length and DNA damage. Sci Rep. 2017 Jun 23;7(1):4137. doi: 10.1038/s41598-017-04448-4.
  5. Grazioli E, Dimauro I, Mercatelli N, Wang G, Pitsiladis Y, Di Luigi L, Caporossi D. Physical activity in the prevention of human diseases: role of epigenetic modifications. BMC Genomics 2017 Nov 14;18(Suppl 8):802. doi: 10.1186/s12864-017-4193-5.
  6. Dimauro I, Scalabrin M, Fantini C, Grazioli E, Beltran Valls MR, Mercatelli N, Parisi A, Sabatini S, Di Luigi L, Caporossi D. Resistance training and redox homeostasis: Correlation with age-associated genomic changes. Redox Biol. 2016 Sep 21;10:34-44.
  7. Dimauro I, Mercatelli N, Caporossi D. Exercise-induced ROS in Heat Shock Proteins response. Free Radic Biol Med. 2016 Mar; 98: 46-55.
  8. Fittipaldi S, Mercatelli N, Dimauro I, Jackson MJ, Paronetto MP, Caporossi D. Alpha B-crystallin induction in skeletal muscle cells under redox imbalance is mediated by a JNK-dependent regulatory mechanism. Free Radic Biol Med. 2015 Sep; 86: 331-42.
  9. Pittaluga M, Sgadari A, Dimauro I, Tavazzi B, Parisi P, Caporossi D. Physical exercise and redox balance in type 2 diabetics: effects of moderate training on biomarkers of oxidative stress and DNA damage evaluated through comet assay. Oxid Med Cell Longev. 2015 Feb; 2015: 981242.
  10. Dimauro I, Grasso L, Fittipaldi S, Fantini C, Mercatelli N, Racca S, Geuna S, Di Gianfrancesco A, Caporossi D, Pigozzi F, Borrione P. Platelet-rich plasma and skeletal muscle healing: a molecular analysis of the early phases of the regeneration process in an experimental animal model. PLoS One. 2014 Jul; 9: e102993.
  11. Ceci R, Beltran Valls MR, Duranti G, Dimauro I, Quaranta F, Pittaluga M, Sabatini S, Caserotti P, Parisi P, Parisi A, Caporossi D. Oxidative stress responses to a graded maximal exercise test in older adults following explosive-type resistance training. Redox Biol. 2014 Dec; 2: 65-72.
  12. Beltran Valls MR, Dimauro I, Brunelli A, Tranchita E, Ciminelli E, Caserotti P, Duranti G, Sabatini S, Parisi P, Parisi A, Caporossi D. Explosive type of moderate-resistance training induces functional, cardiovascular, and molecular adaptations in the elderly. Age (Dordr). 2014 Apr; 36: 759-72.
  13. Fittipaldi S, Dimauro I, Mercatelli N, Caporossi D. Role of exercise-induced reactive oxygen species in the modulation of Heat Shock Protein response. Free Radic Res. 2014 (invited review) Jan; 48: 52-70.
  14. Dimauro I, Pearson T, Caporossi D, Jackson MJ. In vitro susceptibility of thioredoxins and glutathione to redox modification and aging-related changes in skeletal muscle. Free Radic Biol Med. 2012 Dec; 53: 2017-27.
  15. Brunelli A, Dimauro I, Sgrò P, Emerenziani GP, Magi F, Baldari C, Guidetti L, Luigi LD, Parisi P, Caporossi D. Acute exercise modulates BDNF and pro-BDNF protein content in immune cells. Med Sci Sports Exerc. 2012 Oct; 44: 1871-80.