Ruolo Accademico:
Area Scientifica:
(SSD) Settore Scientifico Disciplinare:
Dipartimento di Scienze Motorie Umane e della Salute - Sezione:
Recapiti:
Università di Roma "Foro Italico" Piazza L. de Bosis 6, 00135,
Telefono: +39 06 36733576
Ricevimento:
Curriculum:
Campi di interesse: Metabolismo dell’RNA, Splicing Alternativo, Oncologia molecolare, sarcoma di Ewing.
Curriculum
Professore Associato di Biologia applicata presso il Dipartimento di Scienze Motorie, Umane e della Salute, Università degli Studi di Roma “Foro Italico”, con esperienza di ricerca ed insegnamento nel campo della biologia cellulare e molecolare, regolazione genica e splicing alternativo.
La ricerca della Prof. Paronetto è focalizzata sulla regolazione dell’espressione genica a livello co- e post-trascrizionale, e sulla regolazione dello splicing alternativo da parte di signaling pathways attivati in condizioni fisiologiche e patologiche.
La sua ricerca si propone di studiare la regolazione del processamento degli RNA da parte di RNA binding proteins (RBP), la cui attività è modulata da meccanismi di trasduzione del segnale e programmi di differenziamento cellulare, ed è spesso deregolata in patologie quali le malattie neurodegenerative ed il cancro.
Research Interests: RNA metabolism, alternative splicing, molecular oncology, Ewing sarcoma.
Curriculum
Associate Professor of Applied Biology at the Department of Movement, Human and Health Sciences, University of Rome “Foro Italico”, with teaching and research background in the fields of cellular and molecular biology, gene regulation and alternative splicing.
The aim of Prof Paronetto’s research is focused on co- and post-transcriptional regulation of gene expression, with a specific interest in the regulation of alternative splicing and its modulation by signal transduction pathways.
Her research aims at unraveling the regulation of mRNA processing and gene expression by RNA-binding proteins (RBP) whose activity is modulated by signal transduction pathways and differentiation programs, and is dysregulated in human disease, such as neurodegenerative diseases and cancer.
Curriculum Scientifico:
Curriculum scientifico
Selected publications:
1. Volpe E, Cesari E, Mercatelli N, Cicconi R, De Bardi M, Capone A, Bonvissuto D, Fraziano M, Mattei M, Battistini L, Paronetto MP, Sette C. The RNA binding protein Sam68 controls T helper 1 differentiation and anti-mycobacterial response through modulation of miR-29. Cell Death Differ. 2018 Sep 26.
2. Svetoni F, De Paola E, La Rosa P, Mercatelli N, Caporossi D, Sette C, Paronetto MP. Post-transcriptional regulation of FUS and EWS protein expression by miR-141 during neural differentiation. Hum Mol Genet. 2017 Jul 15;26(14):2732 2746.
3. Passacantilli I, Frisone P, De Paola E, Fidaleo M, Paronetto MP. hnRNPM guides an alternative splicing program in response to inhibition of the PI3K/AKT/mTOR pathway in Ewing sarcoma cells. Nucleic Acids Res. 2017 Dec 1;45(21):12270-12284.
4. Mercatelli N, Fittipaldi S, De Paola E, Dimauro I, Paronetto MP, Jackson MJ, Caporossi D. MiR-23-TrxR1 as a novel molecular axis in skeletal muscle differentiation. Sci Rep. 2017 Aug 3;7(1):7219.
5. Svetoni F, Frisone P, Paronetto MP. Role of FET proteins in neurodegenerative disorders. RNA Biol. 2016 Nov;13(11):1089-1102.
6. Paronetto MP, Passacantilli I, Sette C. Alternative splicing and cell survival: from tissue homeostasis to disease. Cell Death Differ. 2016 Dec;23(12):1919-1929.
7. Fidaleo M, Svetoni F, Volpe E, Miñana B, Caporossi D, Paronetto MP. Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9. Oncotarget. 2015 Oct 13;6(31):31740-57.
8. Paronetto MP, Bernardis I, Volpe E, Bechara E, Sebestyén E, Eyras E, Valcárcel J. Regulation of Exon Definition and Apoptosis by the Ewing Sarcoma Protein. Cell Reports, 2014, 7:1211-26.
9. Naro C, Barbagallo F, Chieffi P, Bourgeois CF, Paronetto MP, Sette C..The centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival. Nucleic Acids Res, 2013, 42:3218-27.
10. Paronetto MP. 2013. Ewing Sarcoma Protein: A Key Player in Human Cancer. Int J Cell Biol, 2013:642853.
11. Cappellari M, Bielli P, Paronetto MP, Ciccosanti F, Fimia GM, Saarikettu J, Silvennoinen O, Sette C. The transcriptional co-activator SND1 is a novel regulator of alternative splicing in prostate cancer cells. Oncogene, 2013, 33:3794-802.
12. Paronetto MP, Miñana B, Valcárcel J. The Ewing Sarcoma protein (EWS) regulates DNA damage-induced alternative splicing. Mol Cell. 2011, 43:353-68.
13. Paronetto MP, Cappellari M, Busà R, Pedrotti S, Vitali R, Comstock C, Hyslop T, Knudsen KE, Sette C. Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68. Cancer Res. 2010 Jan 1;70(1):229-39.
14. Muñoz MJ, Pérez Santangelo MS, Paronetto MP, de la Mata M, Pelisch F, Boireau S, Glover-Cutter K, Ben-Dov C, Blaustein M, Lozano JJ, Bird G, Bentley D, Bertrand E, Kornblihtt AR. DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation. Cell. 2009 May 15;137(4):708-20.
15. Paronetto MP, Messina V, Bianchi E, Barchi M, Vogel G, Moretti C, Palombi F, Stefanini M, Geremia R, Richard S, Sette C. Sam68 regulates translation of target mRNAs in male germ cells, necessary for mouse spermatogenesis. J Cell Biol. 2009 Apr 20;185(2):235-49.
